"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital. Within the framework of this DFG grant the detailed mechanisms underlying aggressive and impulsive behavior will be investigated in close collaboration with many research groups within the consortium (for details see www.trr379.de . Together, these studies may help to develop novel therapeutic approaches, specifically the use of the microbiome and novel genetic factors, which are sorely required due to the rising incidences of aggression in modern societies. To achieve this, the candidate will learn and perform a wide variety of techniques - ranging from behavioral, molecular, histological to microbiota-related analyses using state-of-the-art animal models.